The research work was carried out in collaboration between all authors. View abstract. We currently have no information for JUSTICIA PECTORALIS overview. Watering depends on humidity and temperature. Biomed Res. The aim of this study is to evaluate the effects of J. carnea leaf extract on hematology indices and organ antioxidant system in healthy wistar rats. Further, 0.5ml of supernatant was treated with 0.5ml of Ellmans reagent (containing 19.8mg of 5,5 dithiobis - (2-nitrobenzoic acid) (DTNB) in 100ml of 0.1% sodium nitrate) and 3.0ml of phosphate buffer (0.2M, pH8.0). Springer Nature. Superoxide dismutase was carried out using the method of Sun and Zigma [18]. Star Apple: Amazing Health Benefits of eating its fruits. degree in Biochemistry fromUniversity of Ado-Ekiti, Ekiti State, Nigeria and University of Ibadan, Nigeriarespectively. what are the pros and cons of testosterone replacement therapy? Inflammation is a complex biological response of body's tissue to harmful stimuli like infections, toxins and itself. hindawi publishing corporation evidence-based complementary and alternative medicine. Justicia carnea is commonly cultivated and grown as an ornamental potted plant. In sub-acute toxicity study, total of thirty (30) rats were randomized into six groups of five rats per group: Group 1 served as control and was administered with 1ml of distilled water (dH2O). Antioxidants & redox signaling Forum Review. It helps in replenishing blood lost during period. Ethanol extract of J. carnea leaf elevated red blood cell, hemoglobin, packed cell volume and platelet count with significant increase at higher doses of extracts compared to the control. No observable focal sclerosis of renal glomeruli, capsular spaces around the glomerulus appears normal with distinct layering of renal microcellular structures. Generally disease free. In Nigeria, the leaf of Justicia carnea is usually prepared with edible vegetables to make soup, boiled separately in water to make tea or prepared by cooking with other medicinal plants for therapeutic purposes. Justicia carnea (ewe eje) is used by pregnant women to boost the production of red blood cells and cure anemia in pregnancy. The liver histopathological examination of the groups treated with J. carnea ethanol extract (JCEE) leaf showed normal liver architecture with slight abnormalities (such as mild fat congestion and hemorrhage) in the central venules of groups that received high doses. Despite the therapeutic importance of medicinal plants, toxic substances have been shown to be present in large numbers of plants investigated [3]. View abstract. Join now and start creating your dream garden! Make sure to follow the package instructions carefully. B-vitamins are good sources of energy. The possible anti-anaemic property of the leaf could be linked to the improved hemoglobin, PCV and RBC observed in this study. 50mg/kg-1200mg/kg treatments relative to control showed varied degree of hepatic injury that is dose dependent. Omogunwa is a graduate of Biochemistry from the Department of Chemical Sciences, Olusegun Agagu University of Science and Technology, Okitipupa, Ondo State, Nigeria. 2013;3(4):1248 https://doi.org/10.7324/JAPS.2013.3422. Significant (P<0.05) decrease observed in liver total protein of rat administered with 1200mg/kg of extract could be due to intrinsic factors in-vivo that might not necessarily indicate adverse reaction of the extracts. This is due to the inability of the pancreatic beta cells to secrete insulin, which transports glucose to cells, or the inability of cells of the body to recognize insulin. 200, 500 and 1000 mg/kg bw of Justicia carnea showed a significant (p<0.05) decrease in the activities of ALT, AST and ALP, and bilirubin level while total protein and albumin levels increased significantly (p<0.05) when compared with the rats treated with CCl alone. Joseph, H., Gleye, J., Moulis, C., Fouraste, I., and Stanislas, E. O-Methoxylated C-glycosylflavones from Justicia pectoralis. degree in Biochemistry from Olabisi Onabanjo University, Ago-iwoye, and University of Ibadan, Ibadan, Nigeria respectively. Based on estimation by World Health Organization (WHO), larger percentage (between 80 and 90%) of the worlds population especially in developing countries depends on traditional system of medicine [1, 2]. Studies on The Phytochemical and Nutritional Composition of Aqueous The liver and kidneys were excised and rinsed immediately in a normal saline (0.9% Nacl) to remove blood stain, dried between layers of Whatman filter paper, weighed and homogenized to obtain the supernatant for biochemical analysis. Toxicity studies of medicinal plants used in sub-Saharan Africa. Information from this source is evidence-based and objective, and without commercial influence. In which ever condition, the blood glucose level increases abnormally. Justicia Carnea; Blood-Boosting Green Plant That Turns Hot Water Red! Treatments of experimental animals were in accordance with the Principle of Laboratory Animal Care manual guide of National Institute of Health [14] as approved by the Institution Research Ethics committee. Tietz NW. Biochem Pharmacol. Ewe eje or ewe ajeri is prepared differently by different folks. This requires more attention to properly document the various health benefits of justicia carnea. Nutritional Composition of Ewe eje (Justicia carnea leaf). Rats were routinely observed for signs of toxicity. Cookies, This site is protected by reCAPTCHA and the Google, Justicia scheidweileri (Purple Shrimp Plant), Justicia americana (American Water-Willow), Want Garden Inspiration? Total reaction mixture of 3ml contained 2.95ml of 0.05M sodium carbonate buffer (pH10.2), 0.02ml tissue sample and 0.03ml of epinephrine (2mM) in 0.005N HCl was used to initiate the reaction. Regular intake can reduce your risk of liver diseases like liver cirrhosis, hepatitis and liver inflammation. It may also affect the activity of hormones. Ewe eje as a Natural Blood booster/tonic: Due to the high concentration of iron in this leaf, it can help boost blood production by increasing the red blood cells, haemoglobin, and the blood platelets. 2005;102(2):197201. J Ethnopharmacol. It is an awesome plant and worth your time and attention. Google Scholar. Rich, well-drained soil retaining ample moisture is the perfect home for Brazilian plume flowers. Ethanol extracts of J. carnea leaf increased RBC, hemoglobin and platelet with significant increase (p<0.05) in groups that received higher dose (>500mg/kg b.w) of extract compared to the control. In the winter, temperatures between 60 64 degrees Fahrenheit (15 18 C) are ideal. It is believed by local consumers in Ghana to possess anti-anaemic effects that boost blood levels in pregnant women, anaemic patients and also . As a consequence, depletion of reduced glutathione (GSH) either by removal from the cell or oxidation to GSSG could eventually lead to mild oxidative stress in cells and tissues [33, 34]. Briefly, 1.0ml of the sample was mixed with 2ml of TCA-TBA-HCl reagent (0.37% thiobarbituric acid, 15% trichloroacetic acid and 0.24N HCl in 1:1:1) and boiled at 100C in a water bath for 15min. These minerals help in boosting blood production, which is why the plant is called ogwu obara (blood medicine) among the Igbo people of Southern Nigeria. Justicia carnea is affects Fertility according to a researched article published on ResearchgateJusticia carnea was found to lower sperm count Male Wistar Albino ratsthe effect of this herb on female fertility is not yet known. Medapa S, Singh GRJ, Ravikumar V. The phytochemical and antioxidant screening of Justicia wynaadensis. One of the numerous nutritional benefits of justicia carnea leaves is in the possession of various forms of the B vitamins such as Vitamin B1, B2, B6, B9, and B12. Liver and kidney in all treated groups maintained similar activities of catalase (CAT) compared to the control. The Brazilian Plume is native to mainly tropical areas in South America, meaning it thrives in warm and slightly humid climates. Anthonia OC, Ikechukwu UR, Uzoma NO, Sunday ELU. 4. The minerals present in justicia carnea (Ewe eje or ogwu obara) are calcium, iron, magnesium, copper and zinc. Bottom Line. Inhibitory Potential and Antidiabetic Activity of Leaf Extracts of Justicia carnea. PubMedGoogle Scholar. This encourages better flowering and bushier and denser new growth. Ethnomedical study and iron content of some medicinal herbs used in traditional medicine in cote divoire for the treatment of anaemia. Although, medically, it is advised you see your doctor or a physician before using the leaf for medicinal uses. Diallo A, Gbeassor M, Vovor A, Eklu-Gadegbeku K, Aklikokou K, Agbonon A. Liver superoxide dismutase (SOD) activity was significantly (p<0.05) increased at 1200mg/kg while other tested doses caused no detrimental effect on glutathione, catalase, SOD and malondialdehyde level in liver and kidney. 8-10 Justicia carnea leaves. Acute toxicity was determined in two phases using Lorke method. Arch Toxicol. https://doi.org/10.1016/j.biocel.2006.07.001. They are also needed in strong bone formation, and in cellular and neuronal functions. J Ethnopharmacol. J Ethnopharmacol. Provided by the Springer Nature SharedIt content-sharing initiative. Chariandy, C. M., Seaforth, C. E., Phelps, R. H., Pollard, G. V., and Khambay, B. P. Screening of medicinal plants from Trinidad and Tobago for antimicrobial and insecticidal properties. Phytochemical profile, antioxidant, -amylase inhibition, binding Relative to control, lymphocyte and granulocyte exhibited no significant difference in all doses while MID was elevated in treated groups with significant increase in rats administered with 500 and 800mg/kg body weight. The efficiency of some preexisting anti-obesity drugs was limited by several adverse effects associated with them including gastrointestinal disorder, high risk of cancer, and long-term use detrimental effects on some organs such as liver, kidney and pancreas [ 4, 8 ]. Having discussed the nutritional benefits of ewe eje, i shall now take you through the various health benefits of justicia carnea leaves, and roots. The gradual decrease in the weight of organs following short-term exposure of J. carnea leaf ethanol extract may be attributed to adaptive response of the organs arising from daily dosage of the extract or its metabolites within their body. The liver and kidneys excised from all the experimental rats were fixed in a labeled sample bottles containing 10% formalin and processed for histological examination. To use the website as intended please In these groups, from mild to severe order; the renal cortex appears distorted, Renal glomeruli and dillated capsular spaces appeared collapsed with characteristic pyknosis of the mesangial cells, The renal tubules, interstitial spaces, appears distorted with presence of red inflammatory cells, hemorrhagic cells infiltrating the renal interstitial spaces as well as focal sclerosis of renal glomeruli with associated degeration of the glomerular membrane (red arrows). Occupational Health and Safety in the Care and Use of Research Animals. In some areas, the plant may tolerate temperatures as low as 50 degrees Fahrenheit (10 C). Google Scholar. The leaves of Justicia carnea contains powerful antioxidant activities and phytochemical components that help reduce oxidative stress, and reduce the risk of development of cancer. 2023 BioMed Central Ltd unless otherwise stated. Effects of kolaviron on hepatic oxidative stress in streptozotocin induced diabetes. It has been shown also that other specie of justicia improve central nervous system functions and health and protect it from toxic damages. 2013;1:38898. In-vitro Antioxidant Screening of Ethanol Extracts of Costus afer and Data were analyzed using one-way analysis of variance (ANOVA) using Statistical Product and Service Solutions (SPSS) version 17.0 and results were expressed as meanSEM. statement and Absorbance reading was taken at 620nm regularly at an interval of 1min against reagent blank. Prevent this by spraying the leaves with water. The aim of this study is to evaluate the safety of ethanol extract of J. carnea leaf assessing the hematology indices, organ antioxidant system and histology in healthy male wistar rats. J Nat Prod 1988;51(3):599-600. 1983;53:27589. The significant decrease in kidney GSH at 1200mg/kg could be due to ample dietary bioactive constituents in the extract that requires frequent conjugation of GSH in the cell or oxidation to oxidized glutathione (GSSG). Nutritive properties of aqueous extract Justicia carnea leaves and its effects on haematological and some biochemical indices of anaemia induced male wistar albino rats. Use liquid fertilizers, slow-release or granulated formulas. Lorke D. A new approach to practical acute toxicity testing. The leaves of justicia carnea possess high content of iron and vitamin C. This compounds may be responsible for the blood boosting property of ewe eje leaves. Detection of Bioactive Fractions of Justicia Adhatoda L. Leaves It is not. The spread is equally glorious and can take up 12 15 inches of space. There are several scientific studies which show that the methanolic leaf extract of Justicia carnea protects the liver from toxic effect of carbon tetrachloride harmful effect on the live integrity and functions. In a reaction mixture containing 0.01M phosphate buffer (pH7.0), 0.5ml of 0.2M H2O2 and 0.4ml distilled water, 0.5ml of sample was added. National Research Council. It is nicknamed the Blood leaf, Blood of Jesus, and Jehovah Witness leaf in Nigeria, and is a widely used leaf across states in Nigeria. 400). Different drugs are used but many depend mainly on plants and herbal products for its treatment. It may be, judging from the antidepressant activity of other plant of justicia species whose activity have been studied, proper to state that justicia carnea may possess antidepressant properties. Each of the rats received 1500, 2900 and 5000mg/kg body weight of JCEE respectively and examined within 24h for manifestation of toxicity. J Ethnopharmacol 2000;70(2):151-159. 1978;52:30210. Hepatoprotective Effect of Methanol Extract of Justicia carnea Leaves Ewe eje can increase blood count and volume. In a study conducted by Onyeabor and colleagues, the leaf extract of jusiticia carnea reverses the anemic effect of phenylhydrazine on the pack cell volume, red blood cell, and hemoglobin concentrations. The blood stimulating effects could be due to the presence of dietary bioactive constituents that stimulate activities of haematopoietic cells and stabilization of blood in circulation [21]. Assessment of Aloe vera (L) genotoxic potential on Escherichia coli and plasmid DNA. Contamination of medicinal plant could be as a result of contaminants (such as heavy metals, aflatoxin and pathogenic microbes) from soil and manner of herbal preparations [4]. SOD activity was determined by its ability to inhibit the auto-oxidation of epinephrine determined by the increase in absorbance at 480nm. Anyone you share the following link with will be able to read this content: Sorry, a shareable link is not currently available for this article. Hepatoprotective Effect of Methanol Extract of Justicia carnea Leaves It can be used to manage diabetes consition properly. In an acute exposure of experimental rats to single oral doses of extract, no mortality and signs of adverse effects were observed. Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. View abstract. By entering your email address you agree to receive a daily email newsletter from Plant Care Today. From mild to severe order, the graded doses showed distorted renal cortex with collapsed renal glomeruli and dillated capsular spaces. As declared by all authors, no competing interests exist. Not sure which Justicia to pick?Compare All Justicia. Cut from the stem, some fresh or dried Justicia carnea leaves. Mr. K.O. Mukinda JT, Syce JA. Ashwagandha tea: 10 benefits, side effects and recipes, 7 interesting health facts about Black sapote fruits. 3rd ed. The description of these plants has been written based on numerous outside resources. 1999;9:18. How long does it take for Aju mbaise to work. 1. In traditional medicine, justicia carnea is used in treating hepatitis. Tips on how to get rid of leaf eating caterpillar. Effects of ethanol leaf extract of Justicia carnea on serum SOD Prof. F.O. It also increases good cholesterol levels. Water your plants deeply during growth periods, allowing the soil to dry . Google Scholar. We'll respect your privacy and unsubscribe at any time. Filed in Biochemistry Project Topics, Current Projects by TMLT Editorials on September 22, 2020. Anal Biochem. View abstract. SOD is involved in the dismutation of the highly reactive superoxide anion to molecular oxygen (O2) and to less reactive hydrogen peroxides (H2O2) species, whereas CAT removes hydrogen peroxide (H2O2) and toxic hydroxyl radical into water molecule [35]. Several medicinal plants such as Xylopia aethiopica [25], Tectona grandis [26] and extracts of M. indica, A. hybridus and T. occidentalis [27] have also been reported to elevate RBC, hemoglobin and packed cell volume. Nunes TRS, Cordeiro MF, Beserra FG, et al. Justicia carnea [jus-TEE-see-ah, KAR-nee-uh] is popularly known as the Brazilian Plume Flower. These antibodies help prevent infections and fight off diseases. Previously, J. carnea leaf has been reported to contain high quantity of phytochemical constituents (such as saponins, alkaloids and terpenoids), vitamins (A, C and E) and minerals [9, 10]. Consequently, the effects of the extract on MDA level could indicate damage to cell membrane lipids of the hepatocyte which could result to increased generation of reactive oxygen species (ROS). Photomicrograph of a liver sections stained with Haematoxylin and Eosin (Mag. Each rat was dissected and blood samples were collected by cardiac puncture using 5mL into tubes containing ethylenediaminetetraacetic acid (EDTA) for hematological analysis. View abstract. 2008;79:3326 https://doi.org/10.1016/j.fitote.2008.02.005. long (20 cm), densely packed with pink to crimson tubular flowers. Rather it can assist with improveing liver function such as detoxification. Vitamin C and E are antioxidants. Justicia carnea is a medicinal plant that is used conventionally as blood tonic from time immemorial in Nigeria. View abstract. Colorimetric assay of catalase. Generic and epigenetic contributions to human nutrition and health: managing genome-diet interactions. Kone WM, Koffi AG, Bomisso EL, Tra Bi FH. WBC reduced in rats treated with doses of J. carnea with significant decrease (p<0.05) in rats that received 50, 100 and 1200mg/kg body weight. The effect of the ethanol extract of Justicea. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you. Haematological and biochemical studies on Justicia carnea - PubMed J Ethnopharmacol. Chemical constituents and biological activities of species of Justicia a review. Why urban citizens in developing countries use traditional medicines: the case of suriname. Side Effects, Uses and Health benefit of Ewe eje (Justicia carnea leaf) . Akintimehin is a lecturer in the Biochemistry unit of Chemical Sciences Department, Olusegun Agagu University of Science and Technology, Okitipupa, Ondo State, Nigeria. No. Brazilian-plumeflowers are best propagated from softwood cuttings. 5. The resultant liquid after boiling is usually crimson red. It is commonly referred to as blood root, blood booster, ewe eje in Yoruba, Ogwu obara in Igbo, and jacobinia in Brazil and south America. J Am Diet Assoc. Google Scholar. While the renal tubules across the tested groups were normal with the interstitial spaces showing moderate congestion and hemorrhage, there appeared some abnormalities in the renal cortex (such as few sclerotic glomeruli with moderately dilated capsular spaces) resulting in fair architectural structure of the kidney (Fig. The renal effects of blood glucose-lowering plant-derived extracts in diabetes mellitus-an overview. The liver and kidney of rats administered with 500mg/kg JCEE and above demonstrated slight increase in MDA level with significant (P<0.05) increase only observed in the liver of rats that received 1200mg/kg of extract. Furthermore, increased MID by the extracts could indicate macrophage formation ability and pathogenic scavenging role. 2016;5(1):6270 https://doi.org/10.1016/j.joad.2015.08.006. 2015;15:236. https://doi.org/10.1186/s12906-015-0760-y. For a few weeks, the cutting should be watered every day to promote root development. Aim. Evid Based Complement Alternat Med. Decreased white blood cell count was obtained in this report, the level of lymphocyte and granulocyte was not altered by the extract while MID sized cell was significantly elevated at 500 and 800mg/kg dose. Safety assessment of oral administration of ethanol extract of Justicia At this time there is not enough scientific information to determine an appropriate range of doses for Justicia pectoralis. 1. The roots and the leaves possess medicinal values and have been used in treating several diseases. if you add justicia carnea leaves in avocado seed tea, you may just get yourself the best remedy for cardiovascular diseases. 15 Amazing benefits of brocoli juice and side effects. The shrubby habit of the plant is well-suited for both containers and outside planting. The species Justicia secunda Vahl belongs to the family - Acanthaceae - together with up to 600 other shrubs and herbs species. long (20 cm), densely packed with pink to crimson tubular flowers. Growing up, we were told many biblical stories, Negro pepper (Xylopia aethiopica) is a spice plant that possess several health benefits, which make it an indispensable, Eating for its sour taste when fairly ripen and sweet taste when well ripen, star apple finds favor, Fertility tree (Newbouldia laevis), also known as boundary tree, Ogirisi in Igbo, Adikuru in Hausa and Ewe akoko, Guava (Psidium guajava) is a well known tropical tree which is widely grown for its fruits. aqueous extract J. carnea leaves and its effects on haematological and some biochemical indices of anaemia induced male Wistar albino rats. Research reports it isnt capable of causing kidney and liver damage either but dont eat it raw. Afr J Tradit Complement Altern Med. https://doi.org/10.13040/IJPSR.0975-8232. Too much sun can scorch the leaves, and too little will result in fewer flowers. Hence, Justicia carnea can be used to strengthen the immune system. Parameter that were determined include total haemoglobin concentration (HGB), packed cell volume (PCV), red blood cell count (RBC), mean corpuscular haemoglobin (MCH), mean corpuscular haemoglobin concentration (MCHC), mean corpuscular volume (MCV), white blood cell count (WBC), Lymphocyte count (LYM), MID sized cell (MID), Granulocyte Count (GRM) and platelet count (PLT). 2003;66:1499503. The reference cuvette contained 2.95ml buffer, 0.03ml of substrate (epinephrine) and 0.02ml of water. Justicia carnea is amedicinal plant used widely in Nigeria which is reported to have diverse functions, including blood-boosting potential. The non significant decrease observed in this study is in consonance with the work of Onyeabo et al., [9] who also reported no significant difference in the relative weights of liver and kidney. This lends the plant some interesting names such as Blood of Jesus plant and Hospital too far. Justicia carnea - Wikipedia The present study investigated the antioxidant and in vitro antidiabetic capacities of Justicia carnea aqueous leaf extract (JCAE) using -amylase inhibition model. One of the side-effects of some orthodox drugs used in the past had been excessive inhibition of the carbohydrate-hydrolyzing enzymes, which in turn leads to abdominal discomfort and. The renal cortex showed normal glomeruli with mesangial cells and capsular spaces appeared normal (white arrow), the renal tubules appear normal (blue arrow) and interstitial spaces also observed normal (black arrow). Consumption of medicinal plants without scrutinizing its efficacy and safety can result in unexpected toxic effects resulting in physiology changes of different organs in the body. PDF Haematological and Biochemical Studies on Justicia Carnea Leaves Ogbe RJ, Adoga GI, Abu AH. Clinical Guide to Laboratory tests. J. Appl. Therefore,it is imperative to investigate the effects of the plant on the essential biochemical indices in diabetic rats so as to establish its safety. Emmanuel Sina Akintimehin. It has been reported previously that under certain conditions, dietary antioxidants such as ascorbic acid, tocopherol and carotenoids could act, occasionally, as pro-oxidants to initiate slight degree of oxidative stress microenvironment. Sun M, Zigma S. An improved spectrophotometer assay of superoxide dismutase based on epinephrine autoxidation. List of various diseases cured by Justicia Betonica. 2012;9(1):817 https://doi.org/10.4314/ajtcam.v9i1.12. Despite the avalanche use of medicinal plant, preliminary toxicity studies remain essential tools to ensure safe consumption and prevent unexpected toxicity that could arise from long term exposure. To create additional collections, you must be a paid member of our site. Daily intake of the Ewe eje or ajeri can increase the absorption of iron and vitamins, Uses and health benefits of Ewe eje (Justicia carnea leaf). Author ESA managed the literature searches and wrote the first draft of the manuscript with the assistant of FOA.
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