Weight loss is possible while taking Tapazole if you have a strategy. The most common cause of hyperthyroidism in the United States is Graves disease. He returned 2 months later for radioactive iodine ablation. Methimazole is a reason for the increasing weight of patients during hyperthyroidism treatment. Store at room temperature away from moisture and heat. So far, myositis secondary to carbimazole was described in the context of a lupus-like syndrome or other rare cases of anti-neutrophil cytoplasmic antibodies-associated vasculitis. How to Lose Weight After Stopping Singulair. Check with your doctor immediately if any of the following side effects occur: Some side effects may occur that usually do not need medical attention. I am not diabetic. Each tablet contains 5 or 10 mg (43.8 or 87.6 mol) methimazole, an orally administered antithyroid drug. Graves disease: the most common cause of hyperthyroidism in the United States. After 3 days of hospitalization, he was discharged solely on -blockers. Patient aims to help the world proactively manage its healthcare, supplying evidence-based information on a wide range of medical and health topics to patients and health professionals. You may report side effects to the FDA at 1-800-FDA-1088. appropriate medical assistance immediately. Other than anti-thyroid drugs, -blockers have also been implicated in a lupus-like reaction (7), but our patient had complete resolution of symptoms while he was still on -blockers. Muscle complaints are frequent in patients with thyroid disease. They need to know if you have any of these conditions: Take this medication by mouth with a glass of water. Methimazole-induced myositis is a rare clinical entity. Other studies have shown that after hyperthyroidism treatment patients have a 32% increased risk of obesity and most of this weight gain occurs in the first 2 years after therapy (9). Here are 4 ways you can get more help right now: #1. Advertising on our site helps support our mission. We do not endorse non-Cleveland Clinic products or services. THE FULL ARTICLE TITLE A long journey of gradually reducing MMI dose did cut me back a bit on weight. TSH: thyroid stimulating hormone produced by the pituitary gland that regulates thyroid function; also the best screening test to determine if the thyroid is functioning normally. They do better controlling their thyroid hormones using Regular L-Carnitine. #2. These side effects may go away during treatment as your body adjusts to the medicine. Methimazole has a weight gain effect because it cures Hyperthyroidism. We comply with the HONcode standard for trustworthy health information. As for polymyositis associated with Graves' disease, it is uncommon and occurs in the background of a positive family history of autoimmune diseases and positive antinuclear antibodies (2). Tell your doctor about all your current medicines and any you start or stop using, especially: a blood thinner--warfarin, Coumadin, Jantoven; or. Take your doses at regular intervals to keep a steady amount of the drug in your body at all times. A fourth suggested mechanism would be an immune-mediated reaction inducing a lupus-like syndrome (7). Get my free thyroid downloads, resources, and PDFs here. I had bad hyperthyroidism and lost significant weight 7 months ago. Chiari Malformation: Causes, Symptoms, and Treatments. "Sudden weight loss [by any means] is associated with a loss of . A 29-year-old male patient who has been previously healthy, on no medications, presented for weight loss during the last 6 months. Resolution of symptoms may occur after stopping methimazole. Answer: The most effective treatment for Hyperthyroidism is completely blocking the thyroid glands. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Common side effects of methimazole may include: nausea, vomiting, upset stomach; headache, dizziness, drowsiness; numbness or tingly feeling; rash, itching, skin discoloration; muscle or joint pain; hair loss; or decreased sense of taste. It absolutely can, and it does this by slowing down your metabolism and reducing the amount of energy that the body produces at baseline. Methimazole may also be used for purposes not listed in this medication guide. J Hreiki was involved in the pathology evaluation and report. It is additionally used before thyroid surgery or radioactive iodine treatment. Sign up to receive 20% off your first order. Mayo Clinic does not endorse companies or products. Notes on Weight loss after reduced methimazole dose? Treatment of hyperthyroidism commonly results in weight gain, but the extent of weight gain is not well known. Overdose symptoms may include nausea, vomiting, upset stomach, headache, joint pain, fever, itching, swelling, or pale skin and easy bruising or bleeding. (6) showed that muscle damage in eosinophilic myositis is mediated by local accumulation of eosinophils and subsequent production of interleukin 5. It would be better to take preventative measures to avoid such a situation. You can read more about my own personal health journey and why I am so passionate about what I do. BACKGROUND Methimazole can lower blood cells that help your body fight infections and help your blood to clot. Reducing your dose will allow more thyroid hormone to function which may increase your metabolism. After stopping Methimazole, there could be a variety of reasons for weight loss. If a child is using this medicine, tell your doctor if the child has any changes in weight. I wqas put on 15 mg of Methimazole and about three weeks later I stated puting on weight and was perfectly fine. As a library, NLM provides access to scientific literature. When we stop using it, our diet returns to normal, and weight loss is noticeable, and a sudden weight loss will lead to many other serious health concerns. Version: 4.01. Methimazole acts to block the effects of hyperthyroidism by inhibiting the PRODUCTION and ACTIVATION of thyroid hormone in your body (2). Question: How much weight did patients gain on using Methimazole? Over-blocking thyroid hormone may actually take you from hyperthyroidism to hypothyroidism which may then trigger symptoms such as hair loss, weight gain, fatigue, constipation and so on. There is a potential for serious side effects to an unborn child. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. You may lose up to 5 pounds within the first month you start taking Methimazole. The doctor will diagnose you and recommend the next step. Decreased thyroid hormone production and activation in your body by blocking thyroid function. Myositis is not a classical feature in either situation. The list includes optimal ranges, normal ranges, and the complete list of tests you need to diagnose and manage thyroid disease correctly! A 29-year-old male patient who has been previously healthy, on no medications, presented for weight loss during the last 6 months. METHIMAZOLE (meth IM a zole) treats high thyroid levels (hyperthyroidism) in your body. The .gov means its official. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider. Generic name: methimazole [me-THIM-a-zole] Thyrotoxic myopathy is painless, the creatine phosphokinase is usually normal, and the muscle biopsy findings are not specific, including marked muscle fiber degeneration and atrophy (1). Methimazole can absolutely cause weight gain and it does this by blocking thyroid function and activation in the tissues in your body. effects. This activity reviews methimazole's indications, interactions, adverse effects, and other pharmacodynamic and pharmacokinetic factors. Murata et al. Thus, we describe an unusual case of myositis due to methimazole that was reversed after drug withdrawal. Learn more about the relationship between hyperthyroidism treatment and weight gain. A common symptom of hyperthyroidism is weight loss without trying. Has this happened to anyone else? Some items may interact with your medicine. Table of Contents | PDF File for Saving and Printing, Treatment for hyperthyroidism increases the risk of obesity in some patients, Change In Thyroid Nodule Volume Calculator, Find an Endocrinology Thyroid Specialist, https://www.thyroid.org/thyroid-and-weight/, Clinical Thyroidology for the Public (CTFP). It is also used before thyroid surgery or radioactive iodine treatment. and Privacy Policy and steps will be taken to remove posts identified Its also widely believed that treating and managing hypothyroidism is easier when compared to hyperthyroidism. All rights reserved. These side effects may go away during treatment as your body adjusts to the medicine. Along with its needed effects, methimazole may cause some unwanted effects. . At the time of conception, her mother was receiving therapy for Graves' disease with methimazole 20 mg daily. Adthyza Thyroid Medication Review: Should You Use it. Maintaining the rate at which you digest fats and carbohydrates, controlling your body temperature. Complementary work-up for viral hepatitis including hepatitis A, B, and C; Epstein Barr virus; and cytomegalovirus, as well as serologies for salmonella and brucella, were negative. Include exercises like squats, push-ups, triceps dips and biceps curls for three sets of 15 repetitions. If you have had your thyroid removed or if you underwent radioactive iodine ablation then you will have a more difficult time losing weight when compared to someone who is taking methimazole or PTU. Talk to your care team for more information. From undetectable TSH to now normal range. The treatment of hyperthyroidism is to BLOCK thyroid hormone. https://patient.info/forums/discuss/weight-loss-after-reduced-methimazole-dose--720406. respect of any healthcare matters. NOTE: This medicine is only for you. Rapid clinical and laboratory improvements were evident. Hyperthyroidism weight gain after treatment is a common side effect. Will Taking Thyroid Medication Cause A Heart Attack? Can You Use Neosporin for Anal Fissure: Is It Effective? The reason for this is that methimazole only blocks a portion of thyroid function in the body. In WARN . Reducing the dosage will not help that much, perhaps a little, but still a steroid and that's sometimes what they give patients that can not gain weight. If you are going to need surgery or other procedure, tell your care team that you are using this medication. Do not take double or extra doses. Methimazole can also, without delay, inhibit TPO. Two weeks after stopping methimazole (on admission to the hospital) Two months after stopping methimazole; TSH: 0.35-4.94 <0.005: 0.0001 <0.0005: Free T 4: 0.7-1.48 ng/dl: 2.6 . This content does not have an Arabic version. Maintaining a healthy diet and staying active will aid in weight loss while you take Tapazole. Patient information was obtained from Thyroid Clinic Database at the University Hospitals Birmingham NHS Foundation Trust. This balance may be difficult to achieve with methimazole, but it is always worth attempting. Call your doctor at once if you have: liver problems--nausea, upper stomach pain, itching, tiredness, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes). Keep tightly closed. Additionally, you are less likely to burn fat for energy, leading to weight gain. Methimazole is used to treat hyperthyroidism, a condition where the thyroid gland produces too much thyroid hormone. These mechanisms are less well supported. This list may not describe all possible interactions. Treatment of hyperthyroidism with RAI or anti-thyroid medications is associated with an increased risk of gaining weight and even developing obesity. Emily Aboujaoude, Pharm.D., clinical assistant professor at the Rutgers University Ernest Mario School of Pharmacy, agrees. Eat fresh produce, whole grains, low fat dairy, lean beef, fish, eggs and soybeans to keep you feeling full while eating less. Call your doctor for medical advice about side effects. The muscle biopsy characteristically shows marked atrophy with a predominantly lymphocytic infiltrate (1). In addition, other parasitic infections like hydatidosis, cysticercosis, toxocariasis, and toxoplasmosis (3) would probably have been seen on biopsy. Reddit and its partners use cookies and similar technologies to provide you with a better experience. Steer clear of unhealthy processed foods that are high in sodium, refined sugar and fat, which contribute to weight gain. and I'm proud to say that over 80,000+ people have used them over the last 7 years. People with Hashi's are extremely sensitive to both the thyroid-blocking meds and the thyroid hormone replacement meds. Methimazole is used to treat hyperthyroidism (overactive thyroid). Tell your doctor at once if you develop signs of infection. This activation ramps up the metabolism(1) (usually making patients lose weight), increases heart rate (causing palpitations), increased adrenaline release (making you feel jittery and anxious), and leads to diarrhea (through activation of the GI tract). Methimazole Shouldn't Be Used Long-Term If you are taking methimazole then you should be aware that this medication is NOT intended to be used long-term. feeling of constant movement of self or surroundings, general feeling of discomfort, illness, or weakness, sores, ulcers, or white spots on the lips or in the mouth, swelling of the face, feet, or lower legs, swollen, painful, or tender lymph glands in the neck, armpit, or groin, pain or discomfort in the chest, upper stomach, or throat. This is all well and good but you have to realize a few very important points: #1. #1. https://www.ncbi.nlm.nih.gov/pubmed/24692351, #2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2817786/, #3. https://www.ncbi.nlm.nih.gov/gene/7173, #4. https://www.ncbi.nlm.nih.gov/pubmed/28759749, #5. https://www.ncbi.nlm.nih.gov/pubmed/22990640, #6. https://www.ncbi.nlm.nih.gov/pubmed/19341475, #7. https://www.ncbi.nlm.nih.gov/pubmed/19432125, #8. https://www.ncbi.nlm.nih.gov/pubmed/11531931, #9. https://www.ncbi.nlm.nih.gov/pubmed/12939927. Criteria for diagnosis are history of drug exposure, no history of systemic lupus erythematous prior to the episode, positive antinuclear antibodies (7) (8), and a rapid fall in serologies after stopping the drug (7). The most common cause of hyperthyroidism in the United States is Graves' disease. One of the frequently used medications for hyperthyroidism is methimazole. But just because these therapies and medications may make weight loss difficult, it doesnt mean that losing weight is impossible. Swelling at the base of the neck can occur if your thyroid gland (goiter) is enlarged. Although not all of these side effects may occur, if they do occur they may need medical attention. He was hospitalized. The site is secure. Hey! Some related it to a direct effect of carbimazole on muscle (5) and others related it to a rapid decrease in thyroid hormones resulting in a relative local hypothyroid state within the muscle, which may contribute to the creatine phosphokinase elevation (5). Blocking your thyroid will result in some suppression of normal metabolic function. Correspondence should be addressed to S Farhat Email: Received 2013 Jul 20; Accepted 2013 Jul 24. It may be tempting to opt for a therapy such as having your thyroid removed or getting radioactive iodine ablation to treat your hyperthyroidism but these options are not necessarily better. I am on 10mg Methimazole. The most favorable treatment for you will depend on your physical condition, age, the underlying cause of Hyperthyroidism, and the severity of your condition. Why Do My Knees Hurt When I Start Losing Weight? Patients were also followed in a 1-year extension of the trial, published . Do not take your medication more often than directed. Other risk factors for more weight gain were Graves disease as the cause of the hyperthyroidism, an elevated TSH after treatment, or the requirement of thyroid hormone replacement. According to a study, almost 42 people gained about 12 pounds by blocking their thyroid glands. Hyperthyroidism can cause thinning bones, states MayoClinic.com. Written informed consent was obtained from the patient/patient's mother for publication of this case report. Restart Medical LLC. National Library of Medicine Copyright 2023 Elsevier Inc. All Rights Reserved. Basically, if your thyroid is blocked sufficiently then you may be burning fewer calories at rest when compared to normal healthy adults. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Like anything in life, we need to try and achieve a balance, and if the balance is tipped in favor of hypothyroidism over hyperthyroidism, then there may be negative consequences.
